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Harrison Group @ UCL

Welcome to the Harrison group lab website!

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Here you can find details of our latest publications, the team, news and blog updates.

 

Contact details are provided for any further enquiries.

About Us

We're a small team of researchers based at the Centre for Advanced Biomedical Imaging (CABI) at University College London (UCL). 

 

Led by Dr Ian Harrison, our research is focused on using imaging techniques such as MRI alongside molecular and cellular approaches to understand the pathological processes involved in neurodegeneration, in particular, in Alzheimer's and Parkinson's disease animal models.

 

Our recent work focusses on the glymphatic system, and investigating the role of this brain-wide clearance pathway in neurodegenerative disease, applying novel imaging strategies to quantify glymphatic function in disease models. 

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Latest News and Updates

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Latest Publications

Glymphatic Inhibition Exacerbates Tau Propagation in an Alzheimers Disease Model

These results indicate that by modulating AQP4 function and, consequently, glymphatic clearance, it is possible to modify the propagation and pathological impact of tau in the brain, particularly during the initial stages of the disease. These findings highlight the critical role of the glymphatic system in preserving healthy brain homeostasis and offer valuable insights into the therapeutic implications of targeting this system for managing neurodegenerative diseases characterized by protein aggregation and spread.

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